BMV_model v.1
Brain Metastasis Velocity (BMV) Model calculates rate of distant brain failure after stereotactic radiosurgery for brain metastasis.
Calculates rate of distant brain failure after stereotactic radiosurgery for brain metastasis. Stratifying patients into high and low BMV categories can allow providers to better counsel patients on their risks of requiring additional treatments in the future, such additional SRS or whole brain radiation therapy.
Use for patients with any primary cancer who have developed a distant brain failure (new brain metastasis) after upfront stereotactic radiosurgery (SRS). Developed to predict outcomes at the time of salvage treatment after upfront SRS. Correlates with overall survival, neurologic death, and time to additional salvage treatments by placing patients into low, intermediate, and high risk groups. Primary cancers with the largest representation in the study were breast, lung, RCC, and melanoma. BMV, per year = x / y, where the variables are as follows: x = number of new brain metastases since initial SRS y = total time interval between initial SRS and appearance of new brain metastases, in years. Interpretation: BMV Risk group Median overall survival <4 Low 12.4 months 4-13 Intermediate 8.2 months >13 High 4.3 months
Not appropriate for use in patients who have had prior whole brain radiation therapy.
1. Farris M, Mctyre ER, Cramer CK, et al. Brain Metastasis Velocity: A Novel Prognostic Metric Predictive of Overall Survival and Freedom From Whole-Brain Radiation Therapy After Distant Brain Failure Following Upfront Radiosurgery Alone. Int J Radiat Oncol Biol Phys. 2017;98(1):131-141.
EVALUATION.bmv_model.v0
