Maryam Razavi

maryam.razavi@cambio.se

Cambio CDS

To calculate the total sum for the RoPE score

Use to Identify stroke-related PFO in patients with cryptogenic stroke. Variables and assigned points: No history of hypertension +1 No history of diabetes +1 No history of stroke or TIA +1 Nonsmoker +1 Cortical infarct on imaging +1 Age in years 18-29 +5 30-39 +4 40-49 +3 50-59 +2 60-69 +1 ≥70 0 Formula: Addition of selected points Score interpretation: RoPE score PFO-attributable fraction (95% CI) Estimated stroke/TIA recurrence at 2 years 0-3 0% (0–4) 20% (12–28) 4 38% (25–48) 12% (6–18) 5 34% (21–45) 7% (3–11) 6 62% (54–68) 8% (4–12) 7 72% (66–76) 6% (2–10) 8 84% (79–87) 6% (2–10) 9-10 88% (83–91) 2% (0–4)

Not to be used in other compelling cause for stroke.

1. Kent DM, Ruthazer R, Weimar C, Mas JL, Serena J, Homma S, Di Angelantonio E, Di Tullio MR, Lutz JS, Elkind MS, Griffith J, Jaigobin C, Mattle HP, Michel P, Mono ML, Nedeltchev K, Papetti F, Thaler DE. An index to identify stroke-related vs incidental patent foramen ovale in cryptogenic stroke. Neurology. 2013 Aug 13;81(7):619-25. doi: 10.1212/WNL.0b013e3182a08d59. Epub 2013 Jul 17. PMID: 23864310; PMCID: PMC3775694. 2. Prefasi D, Martínez-Sánchez P, Fuentes B, Díez-Tejedor E. The utility of the RoPE score in cryptogenic stroke patients ≤50 years in predicting a stroke-related patent foramen ovale. Int J Stroke. 2016 Jan;11(1):NP7-8. doi: 10.1177/1747493015607505. PMID: 26763040. 3. Kent DM, Saver JL, Ruthazer R, Furlan AJ, Reisman M, Carroll JD, Smalling RW, Jüni P, Mattle HP, Meier B, Thaler DE. Risk of Paradoxical Embolism (RoPE)-Estimated Attributable Fraction Correlates With the Benefit of Patent Foramen Ovale Closure: An Analysis of 3 Trials. Stroke. 2020 Oct;51(10):3119-3123. doi: 10.1161/STROKEAHA.120.029350. Epub 2020 Sep 14. PMID: 32921262; PMCID: PMC7831886.

OBSERVATION.rope.v0, EVALUATION.rope_assessment.v0