PREVAIL_Model_guideline v.1
PREVAIL Model for Prostate Cancer Survival Predicts overall survival in chemotherapy-naive patients with metastatic castration-resistant prostate cancer.
To predict overall survival in chemotherapy-naive patients with metastatic castration-resistant prostate cancer.
Note: This calculator has not been externally validated. Variables and points are as follows: - Treatment with enzalutamide planned: Yes=0, No=1 - Current PSA value, ng/mL: Continuous - Time since diagnosis, months: Continuous - Albumin, g/dL: Continuous - Hemoglobin, g/dL: Continuous - Neutrophil to lymphocyte ratio (neutrophil number divided by lymphocyte number) <2.5: Yes=0, No=1 - LDH below upper limit of normal: Yes=0, No=1 - Pain 0-1 (on a scale of 0-10, 10 being the worst pain imaginable, highest pain rating in last 24 hrs): Yes=0, No=1 - <10 bone metastases on bone scan: Yes=0, No=1 - Alkaline phosphatase less than upper limit of normal: Yes=0, No=1 - Pattern of spread: No visceral liver metastases=0, Any visceral liver metastases=1 Formula: Total score = (treatment x 18.1376) + [(ln(PSA) + 2.3026) x 9.52244917] + [(275.9 - time) x 0.1543483] + [(4.9 - albumin) x 16.0447656796] + [(16.8 - hemoglobin) x 7.7519235] + (neutrophil x 17.613) + (LDH x 19.00635) + (pain x 12.2248) + (bone x 17.7533) + (alkaline x 10.9685) + (spread x 32.991)
1. Armstrong AJ, Lin P, Higano CS, Sternberg CN, Sonpavde G, Tombal B, Templeton AJ, Fizazi K, Phung D, Wong EK, Krivoshik A, Beer TM. Development and validation of a prognostic model for overall survival in chemotherapy-naïve men with metastatic castration-resistant prostate cancer. Ann Oncol. 2018 Nov 1;29(11):2200-2207. doi: 10.1093/annonc/mdy406. PMID: 30202945; PMCID: PMC6888025. 2. Armstrong AJ, Lin P, Tombal B, Saad F, Higano CS, Joshua AM, Parli T, Rosbrook B, van Os S, Beer TM. Five-year Survival Prediction and Safety Outcomes with Enzalutamide in Men with Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer from the PREVAIL Trial. Eur Urol. 2020 Sep;78(3):347-357. doi: 10.1016/j.eururo.2020.04.061. Epub 2020 Jun 9. PMID: 32527692.
OBSERVATION.lab_test_psa.v1, OBSERVATION.laboratory_test_result-serum_albumin.v1, OBSERVATION.lab_test-full_blood_count.v1, OBSERVATION.prevail.v0
