Manning_Criteria_for_IBS v.1

Manning Criteria for Diagnosis of Irritable Bowel Syndrome (IBS)

Daniel Keszthelyi

models@cambiocds.com

Determining the likelihood of irritable bowel syndrome diagnosis based on clinically significant criteria.

The Manning Criteria were developed to help predict which patients will de diagnosed with IBS, i.e. will not have any organic disease identified after complete work-up. In a setting where work-up resources are limited, or take undue time, these may be particularly useful. IBS is a ‘rule-out’ diagnosis, which is to say all other possibilities must be ruled out first. The Manning Criteria is the addition of positive criterion: - Onset of pain linked to more frequent bowel movements - Looser stools associated with onset of pain - Pain relieved by passage of stool - Noticeable abdominal bloating - Sensation of incomplete evacuation more than 25% of the time - Diarrhea with mucus more than 25% of the time If no red flag signs are present, a patient likely has IBS when at least 3 of the 6 criteria are met with 63-90% sensitivity and 70-93% specificity.

Keep in mind studies have found highly variable diagnostic performance of the criteria.

[1] Manning AP, Thompson WG, Heaton KW, Morris AF (1978). 'Towards positive diagnosis of the irritable bowel.'. Br Med J 2 (6138): 653–4.doi:10.1136/bmj.2.6138.653. PMC 1607467. PMID 698649. [2] Fass R, Longstreth GF, Pimentel M et al. (2001). 'Evidence- and consensus-based practice guidelines for the diagnosis of irritable bowel syndrome'. Arch. Intern. Med. 161(17): 2081–8. doi:10.1001/archinte.161.17.2081. PMID 11570936. [3] Validation of the Rome III criteria for the diagnosis of irritable bowel syndrome in secondary care.'. Gastroenterology. 145: 1262–70.e1. Dec 2013.doi:10.1053/j.gastro.2013.08.048. PMID 23994201

OBSERVATION.manning_criteria.v0, EVALUATION.manning_assessment.v0