EUTOS_score_CML v.1
EUTOS Score for Chronic Myelogenous Leukemia (CML) predicts outcomes after CML treatments, specifically adjusted for tyrosine kinase treatments.
To predict outcomes after CML treatments.
Use in newly-diagnosed patients before starting therapy. EUTOS Score = (7 × basophil) + (4 × spleen), where “Basophil” is basophils as a percentage of peripheral blood leukocytes, and “Spleen” is spleen size palpable below left costal margin, in cm. Probability of not achieving complete cytogenic response (CCyR) at 18 months = x / (1 + x), where x = exp(−2.1007 + 0.0700 × basophils + 0.0402 × spleen size) Interpretation: EUTOS Score Risk category 5 year progression-free survival CCyR at 18 months ≤87 Low 90% 86% >87 High 82% 66%
1. Hasford J, Baccarani M, Hoffmann V, Guilhot J, Saussele S, Rosti G, Guilhot F, Porkka K, Ossenkoppele G, Lindoerfer D, Simonsson B, Pfirrmann M, Hehlmann R. Predicting complete cytogenetic response and subsequent progression-free survival in 2060 patients with CML on imatinib treatment: the EUTOS score. Blood. 2011 Jul 21;118(3):686-92
EVALUATION.eutos_score_cml.v0
