Dynamic_International_Prognostic_Scoring_System_for_Myelofibrosis v.1

Dynamic international prognostic scoring system for myelofibrosis

Jack Msonkho

models@cambiocds.com

@Cambio CDS

Estimates survival in patients with primary myelofibrosis.

The DIPSS is used to estimate the survival in patients with myelofibrosis using the formula below per observation: FORMULA Addition of the selected points: Variable 0 points 1 point 2 points Age, years ≤65 >65 -- White blood cell count, x109/dL ≤25 >25 -- Hemoglobin, g/dL ≥10 -- <10 Peripheral blood blasts <1% ≥1% -- Constitutional symptoms No Yes -- After an observation DIPSS estimates survival in patients with primary myelofibrosis using the below evaluation: Interpretation: DIPSS Score Risk category Median survival 0 Low Not reached 1–2 Intermediate-1 14.2 years 3–4 Intermediate-2 4 years 5–6 High 1.5 years

Passamonti F, Cervantes F, Vannucchi AM, et al. A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment). Blood. 2010;115(9):1703-8. Validation Gangat N, Caramazza D, Vaidya R, et al. DIPSS plus: a refined Dynamic International Prognostic Scoring System for primary myelofibrosis that incorporates prognostic information from karyotype, platelet count, and transfusion status. J Clin Oncol. 2011;29(4):392-7. Rumi E, Cazzola M. Diagnosis, risk stratification, and response evaluation in classical myeloproliferative neoplasms. Blood. 2017;129(6):680-692.

OBSERVATION.dynamic_international_prognostic_scoring_system_for_myelofibrosis.v0, EVALUATION.dynamic_international_prognostic_scoring_system_for_myelofibrosis.v0