Dynamic international prognostic scoring system for myelofibrosis
Estimates survival in patients with primary myelofibrosis.
The DIPSS is used to estimate the survival in patients with myelofibrosis using the formula below per observation: FORMULA Addition of the selected points: Variable 0 points 1 point 2 points Age, years ≤65 >65 -- White blood cell count, x109/dL ≤25 >25 -- Hemoglobin, g/dL ≥10 -- <10 Peripheral blood blasts <1% ≥1% -- Constitutional symptoms No Yes -- After an observation DIPSS estimates survival in patients with primary myelofibrosis using the below evaluation: Interpretation: DIPSS Score Risk category Median survival 0 Low Not reached 1–2 Intermediate-1 14.2 years 3–4 Intermediate-2 4 years 5–6 High 1.5 years
Passamonti F, Cervantes F, Vannucchi AM, et al. A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment). Blood. 2010;115(9):1703-8. Validation Gangat N, Caramazza D, Vaidya R, et al. DIPSS plus: a refined Dynamic International Prognostic Scoring System for primary myelofibrosis that incorporates prognostic information from karyotype, platelet count, and transfusion status. J Clin Oncol. 2011;29(4):392-7. Rumi E, Cazzola M. Diagnosis, risk stratification, and response evaluation in classical myeloproliferative neoplasms. Blood. 2017;129(6):680-692.
OBSERVATION.dynamic_international_prognostic_scoring_system_for_myelofibrosis.v0, EVALUATION.dynamic_international_prognostic_scoring_system_for_myelofibrosis.v0