DAS28-CRP v.1
Disease activity score 28-CRP (DAS28-CRP) is a calculated score for assessing disease activity in individuals with rheumatoid arthritis (RA). It is calculated from a formula using four parameters: the number of tender (0 - 28) and swollen (0 - 28) joints the patient has, the visual analogue scale score (0 - 100) for patient global assessment of the level of disease activity [0.0 = low disease activity/patient doing very well; 100.0 = high disease activity/patient doing very poor], and the patient's circulating level of the inflammatory biomarker C-reactive protein (CRP). The 28 joints assessed are the left and right shoulder, elbow, wrist, metacarpophalangeal, proximal interphalangeal and knee. DAS28-CRP is a very strong predictor of disability and radiological progression in RA. A score <2.6 is regarded as RA in remission; 2.6 to <3.2 is low disease activity, 3.2 to <=5.1 is moderate disease activity while >5.1 is high disease activity.
This guide calculates the disesase activity score 28-CRP (DAS28-CRP) which is a measure of disease activity and treatment response in individuals with rheumatoid arthritis.
Use to calculate DAS28-CRP, based on four input parameters: tender joint count (TJC), swollen joint count (SJC), patient global assessment of disease activity (PtGDA), and level of C-reactive protein (in mg/dl). PtGDA uses the unit 'mm'. DAS28-CRP = (0.56*√(TJC)+0.28*√(SJC)+0.36*ln(CRP + 1)+0.014*PtGDA +0.96). The assessment of DAS28-CRP is performed by a separate application: DAS28-CRP_Assessment.v1
Anderson J, Caplan L, Yazdany J, Robbins ML, Neogi T, Michaud K, Saag KG, O'dell JR, Kazi S. Rheumatoid arthritis disease activity measures: American College of Rheumatology recommendations for use in clinical practice. Arthritis care & research. 2012 May 1;64(5):640-7. Wells G, Becker JC, Teng J, Dougados M, Schiff M, Smolen J, Aletaha D, Van Riel PL. Validation of the 28-joint Disease Activity Score (DAS28) and European League Against Rheumatism response criteria based on C-reactive protein against disease progression in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythrocyte sedimentation rate. Annals of the rheumatic diseases. 2009 Jun 1;68(6):954-60.
OBSERVATION.disease_activity_score_28_crp.v1, OBSERVATION.disease_activity_index_joint_score.v1, OBSERVATION.lab_test_c_reactive_protein.v1, OBSERVATION.patient_global_assessment_arthritis_activity.v1, EVALUATION.disease_activity_score_28_crp.v1
