Absolute_Reticulocyte_Count_Index v.1

Absolute Reticulocyte Count & Reticulocyte Index that assesses appropriate response to anemia, frequently in sickle cell patients.

Therese Lindberg

therese.lindberg@cambio.se

Cambio CDS

Assesses appropriate response to anemia, frequently in sickle cell patients.

Determining if an anemic patient is mounting an appropriate response to their anemia, or if they have an inadequate marrow response (either from the marrow itself or a nutrient deficiency, or the blood loss was too rapid for reticulocyte response). Patients with an appropriate marrow response (high reticulocyte index) typically are not evaluated further. Patients with an inappropriate marrow response (low reticulocyte index) may be further evaluated for nutritional deficiencies or marrow abnormalities. Always consider transfusion and/or iron supplementation in anemic patients. Absolute reticulocyte count = # or % retics * (pt's Hct / normal Hct). Reticulocyte index = absolute reticulocyte count / maturation factor. Where: Hematocrit Maturation factor ≥35% 1.0 25 to <35% 1.5 20 to <25% 2.0 <20% 2.5 Index interpretation: Index≥2: Adequate response Index <2: Hypoproliferation

1. Priya P P, A.R. S. Role of Absolute Reticulocyte Count in Evaluation of Pancytopenia-A Hospital Based Study. Journal of Clinical and Diagnostic Research : JCDR 2014;8(8):FC01-FC03.

EVALUATION.absolute_reticulocyte_count_index.v0